What is the PMFs
A joint study by the US Department of Agriculture and KGK Synergize, a Canadian nutraceutical company, identified a class of compounds isolated from orange and tangerine peels that shows promise in animal studies as a potent, natural alternative for lowering LDL cholesterol (so-called ‘bad' cholesterol), without the possible side effects, such as liver disease and muscle weakness, of conventional cholesterol-lowering drugs.
The findings, released in the Journal of Agricultural and Food Chemistry, a peer-reviewed publication of the American Chemical Society, the world's largest scientific society, show that the compounds, called polymethoxylated flavones (PMFs), are similar to other plant pigments found in citrus fruits that have been increasingly linked to health benefits, including protection against cancer, heart disease and inflammation.
The main polymethoxylated flavones (PMFs) exist in citrus are:
TANGERETIN
NOBILETIN
SINENSETIN
Scientific support
The above joint study has shown that PMFs have the most potent cholesterol-lowering effect of any other citrus flavonoids and also PMFs have the potential to rival and even beat the cholesterol-lowering effect of some prescription drugs, without the risk of side effects.
Using hamster models with diet-induced high cholesterol, the researchers showed that feeding them food containing 1 per cent PMFs lowered levels of LDL cholesterol by 32 to 40 per cent.
Previous animal studies by others have shown that similar flavonoids, particularly hesperidin from oranges and naringin from grapefruit, also may have the ability to lower cholesterol, although not as effectively as PMFs.
Treatment with PMFs did not appear to have any effect on levels of HDL cholesterol, or good cholesterol,No negative side effects were seen in the animals that were fed the compounds,
The researchers are currently exploring the compound's mechanism of action on cholesterol metabolism. They now suspect, based on early results in cell and animal studies, that it works by inhibiting the synthesis of cholesterol and triglycerides inside the liver.
A long-term human study of the effect of PMFs on high LDL cholesterol is now in progress. While drinking citrus fruits is full of health benefits, taking PMF supplements could be an easier way to lower cholesterol, since a person would have to drink 20 or more cups a day of orange or tangerine juice to have a therapeutic effect.
* Sino-Future provide bulk powder of PMFs
(Standardized to 30%, 60% nobiletin + tangeretin)
Package: 100g, 1kg, 25kg.
* Above information is only knowledge,not an instruction of usage for this product.
